Advances in Neural Science, Volume 2 (Advances in Neural - download pdf or read online

By Sudarshan K. Malhotra

ISBN-10: 0080526403

ISBN-13: 9780080526409

ISBN-10: 1559386258

ISBN-13: 9781559386258

A part of a chain which goals to hide fresh wisdom within the box of neural technological know-how, this quantity discusses such subject matters as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.

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Lobo and Parnavelas (1988) have examined the ontogeny of NT-binding sites in the rat visual cortex using in situ receptor autoradiography. The distribution of NT receptor binding sites undergoes considerable change during ontogeny. Moderate densities of binding sites are present in the occipital cortex as early as El4 and E18. The density of NT-binding sites is extremely high in the occipital region at the time of birth, with a gradual decline starting in the second postnatal week to very low levels in the adult.

The ontogeny of SP receptors in the developing brain has not been systematically examined, except in the spinal cord (Charlton and Helke, 1986). Light microscopic autoradiography and membrane homogenate binding of 125I-Bolton-Hunter-SP was used to study SP binding sites in the spinal cord of rats of different ages. In pups up to 15 days old, binding sites are diffusely distributed over the grey matter and become progressively more defined in specific nuclei as the rats age. High densities of binding sites have been noted at P1 in a nucleus located in the ventrolateral ventral horn of caudal segments; whereas in the phrenic motor nucleus and in the dorsal horn binding sites are expressed after P8.

On the other hand, TTX may exert its effects at the level of biosynthesis. Factors that regulate VIP content and release have also been examined in the bovine fetal adrenal glands by Cheung (1988). Cheung and Hotzwarth (1986) have also reported that VIP is present in the adrenal of the near-term bovine fetus and that VIP can stimulate catecholamine release from fetal adrenomedullary cells in vitro. Adrenal VIP content, as measured by radioimmunoassay, is low at 70 and 80 days of gestation. This is followed by a rapid increase in VIP content from 80 to 110 days, reaching a plateau between 110 and 130 days at levels comparable to that in the adult.

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Advances in Neural Science, Volume 2 (Advances in Neural Science) by Sudarshan K. Malhotra

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