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Extra resources for Advanced Genetic Analysis: Finding Meaning in a Genome
The sickle cell mutation in humans, which becomes dominant at high altitudes, is another example of this type of genotype~environmentinteraction. Such cases are not common. The vast majority ofloss-of-funetion mutants are phenotypically recessive. One of the virtues ofdiploidy is that we apparently can tolerate such 50% reductions in protein production for many, ifnot most, ofour genes. Still, one presumes that many 50% reductions in the normal gene dosage, as would occur in individuals heterozygous for large deficiencies, might be deleterious.
We should also note that a series of terms used 10 describe molecular events have been borrowed from the terminology used to describe chromosome rearrangement. The meanings of most of these terms, such as inversion, duplication, and deletion (or deficiency) are self-evident. The term translo 5. One just needs to be able to isolate the mutants, and then know what to do with those mutants once they are obtained. RSH's thesis advisor, the eminent Larry Sandler often got quite aggravated when asked by a genetically naive colleague whether or not he thought it was "possible" to generate mutants of some given phenotype. "Of course, you can! You can get any mutant you want," Larry would bellow from his office, "I could mutate E. " That may be stretching it a bit, but if you think enough about a given biological process, you can devise a screen for obtaining mutants in the process.
Advanced Genetic Analysis: Finding Meaning in a Genome by R. Scott Hawley
5. One just needs to be able to isolate the mutants, and then know what to do with those mutants once they are obtained. RSH's thesis advisor, the eminent Larry Sandler often got quite aggravated when asked by a genetically naive colleague whether or not he thought it was "possible" to generate mutants of some given phenotype. "Of course, you can! You can get any mutant you want," Larry would bellow from his office, "I could mutate E. " That may be stretching it a bit, but if you think enough about a given biological process, you can devise a screen for obtaining mutants in the process.