By Tomaz Jarm, Peter Kramar
This quantity offers the lawsuits of the first international Congress on Electroporation and Pulsed electrical Fields in Biology, drugs and foodstuff & Environmental applied sciences (WC2015). The congress came about in Portorož, Slovenia, throughout the week of September sixth to tenth, 2015. The clinical a part of the Congress lined assorted elements of electroporation and similar applied sciences and incorporated the next major issues:
· software of pulsed electrical fields expertise in foodstuff: demanding situations and opportunities
· electric impedance size for evaluate of electroporation yield
· Electrochemistry and electroporation
· Electroporation meets electrostimulation
· Electrotechnologies for foodstuff and biomass treatment
· nutrition and biotechnology applications
· In vitro electroporation - easy mechanisms
· Interfacial behaviour of lipid-assemblies, membranes and cells in electrical fields
· Irreversible electroporation in medical use
· scientific purposes: electrochemotherapy
· scientific purposes: gene therapy
· Non-electric field-based actual tools inducing mobile poration and more desirable molecule transfer
· Non-thermal plasmas for foodstuff safeguard, environmental purposes and scientific treatments
· PEF for the foodstuff undefined: basics and applications
· PEF proce
ss integration - complicated method chains and strategy mixtures within the nutrients industry
· Predictable animal models
Pulsed electrical fields and electroporation applied sciences in bioeconomy
· Veterinary clinical applications
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Additional info for 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies: Portorož, Slovenia, September 6 –10, 2015
Furthermore, the vascular disrupting effect, which leads to a cascade of cell death in neighboring tumor cells, may substantially contribute to the overall effectiveness of electrochemotherapy. How much is the contribution of this indirect effect in addition to the direct effect on tumor cells, is still not known and needs to be established. Certainly it varies according to the perfusion level or the vascularization of the tumors, therefore it will be difficult to determine the contribution of the vascular disrupting effectiveness of electrochemotherapy.
Its clinical use is in the treatment of cutaneous and subcutaneous tumors of different histology with the response rate of approximately 70-80% . The treatment is acknowledged in many European countries and is entering routine clinical practice. Lately, this technological approach, using electroporation for chemotherapeutic drug delivery, is being translated also into treatment of deep seated tumors. The technology is being modified and is in clinical testing for liver, bone, brain and colorectal tumors .
When the pulse duration is shortened into the picosecond range (psPEF) the dielectric, rather than the resistive, properties of the outer medium and cytoplasm begin to determine the coupling between electric field and cell membranes. Besides entering a new field of electric field - cell interactions, the use of picosecond pulses allows the application of wideband antennas, rather than invasive electrodes, for the delivery of psPEF to tissue. Keywords— nanosecond pulsed electric fields, picosecond pulses, wideband antennas, cell death, neural stimulation.
1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies: Portorož, Slovenia, September 6 –10, 2015 by Tomaz Jarm, Peter Kramar